helmholtzzentrum münchen

Publications

Two relevant publications per subproject (TP), not necessarily recent

TP1 (Qualitative Modeling):

Antonov et al. (2008): KEGG spider: interpretation of genomics data
in the context of the global gene metabolic network. Genome Biol. 
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Mewes et al. (2008): MIPS: analysis and annotation of genome
information in 2007. Nucleic Acids Res.
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TP2 (Quantitative Modeling):

Cakir et al. (2006): Integration of metabolome
data with metabolic networks reveals reporter reactions. Mol Syst Biol.
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Modre-Osprian et al. (2009): Dynamic
simulations on the mitochondrial fatty acid beta-oxidation network. BMC Syst Biol.
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TP3 (Data Integration):

Kerrien et al. (2007): Broadening the horizon – level 2.5 of the HUPO-PSI format for
molecular interactions. BMC Biol.
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Orchard et al. (2007): The minimum information required for reporting a molecular interaction experiment (MIMIx). Nature Biotech.
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TP4 (Metabolomics):

Gieger et al. (2008): Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet.
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Suhre et al. (2008): MassTRIX: mass translator into pathways. Nucleic Acids
Res.
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TP5 (Lipidomics):

Binder et al. (2006): Metabolic profiling of glycerophospholipid synthesis
in fibroblasts loaded with free cholesterol and modified low density lipoproteins. J Biol Chem.
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Wiesner et al., (2009): Lipid profiling of FPLC-separated lipoprotein
fractions by electrospray ionization tandem mass spectrometry. J Lipid Res.

TP6 (Human Genetics):

Hartig et al. (2006): Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation. Ann Neurol.
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Winkelmann et al. (2007): Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genet.

TP7 (Population Genetics):

Lettre et al. (2008): Identification of ten loci associated with height highlights new biological pathways in human growth. Nature Genet.
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Zeggini et al. (2008): Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility lo-ci for type 2 diabetes. Nature Genet.
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TP8 (Human Studies):

Laumen et al. (2008): Functional characterization of promotor variants of the adiponectin gene complemented by epidemiological data. Diabetes
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Gieger et al. (2008): Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet.
More...

TP9 (Mitochondriopathies):

Scarpulla et al. (2006): Nuclear control of respiratory gene expression in mammalian cells. J Cell Biochem
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Bastin et al. (2008): Activation of peroxisome proliferators activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components. J Clin Endocrinol Metab
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TP10 (Animal Models):

Aigner et al. (2008): Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am J Physiol. Endocrinol. Metab.
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Neschen et al. (2007): n-3 fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. Diabetes
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TP11 (Clinical Lipidomics):

Gempel et al. (2007): The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene. Brain
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Windpassinger et al. (2008): Novel X-linked myopathy with postural muscle atrophy and generalized hypertrophy termed XMPMA, is caused by mutations in FHL1. Am J Hum Genet
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