helmholtzzentrum münchen


Systems Biology, in contrast to the traditional mode of examining single pathophenotypes and the classification of disease types following the diagnosis, takes a fresh look at etiology and courses of disease. Unravelling the sequence of the human genome was followed by an unprecedented accumulation of information concerning the function and role of the genetic elements.

For the first time, comprehensive investigations of the genetic predisposition for both rare and common disorders became possible. However, genetic factors themselves only contribute to disease development; life style, age, nutrition, and other environmental factors also influence onset and course of diseases. Recent developments in the field of functional genomics and genomic epidemiology lend themselves to a system based approach which has the potential to better understanding of disease processes.

SysMBo – Systems Biology of Metabotypes

The funding period of the SysMBo Consortium ended on Dec 31, 2012.
We are looking back on a very fruitful collaboration and succesful publication of numerous scientific articles. We are looking forward towards following the research path started in this collaborative effort.

SysMBo is an interdisciplinary research consortium aiming to unravel the complex relations between genetic predisposition, environmental stimuli and disease. With the help of high-throughput metabolite profiling and powerful modelling tools, the researchers take a system based approach in order to understand the complex interplay between numerous factors leading to a pathophenotype.

The projects will address central properties of biological systems; they converge through a focus on metabolic lipid profiles which are modified in particular genetic backgrounds (Fig. 1).

Fig. 1 Organelles, cell, organs, and diseases as dimensions covered by SysMBo